The p53 target gene TRIM22 directly or indirectly interacts with the translation initiation factor eIF4E and inhibits the binding of eIF4E to eIF4G
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چکیده
منابع مشابه
Small-Molecule Inhibition of the Interaction between the Translation Initiation Factors eIF4E and eIF4G
Assembly of the eIF4E/eIF4G complex has a central role in the regulation of gene expression at the level of translation initiation. This complex is regulated by the 4E-BPs, which compete with eIF4G for binding to eIF4E and which have tumor-suppressor activity. To pharmacologically mimic 4E-BP function we developed a high-throughput screening assay for identifying small-molecule inhibitors of th...
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ژورنال
عنوان ژورنال: Biology of the Cell
سال: 2012
ISSN: 0248-4900
DOI: 10.1111/boc.201100099